1.
Ross Fiziol Zh Im I M Sechenova
; 98(8): 1021-9, 2012 Aug.
Artigo
em Russo
| MEDLINE
| ID: mdl-23155627
RESUMO
Exenatide effect was studied in 55 human including 38 patients with type 2 diabetes mellitus without signs of diabetic nephropathy and primary renal diseases. Preliminary study with water load in volume from 0.5 to 1% b.w. showed that water load equal to 0.7% b.w. caused significant increase in urine excretion. The rise of diuresis after 10 microg Byetta (exenatide) injection and simultaneous water load of 0.7% of b.w. depended on increase in solute-free water clearance. Thus, exenatide (mimetic of GLP-1) action let us to consider its possible role as component of osmoregulation system in human. This peptide provides high efficiency of renal function in osmotic homeostasis.
Assuntos
Diabetes Mellitus Tipo 2/metabolismo , Hipoglicemiantes/administração & dosagem , Rim/metabolismo , Osmose/efeitos dos fármacos , Peptídeos/administração & dosagem , Peçonhas/administração & dosagem , Água/metabolismo , Adulto , Idoso , Diabetes Mellitus Tipo 2/fisiopatologia , Diurese/efeitos dos fármacos , Exenatida , Feminino , Homeostase/efeitos dos fármacos , Humanos , Rim/fisiopatologia , Testes de Função Renal , Masculino , Pessoa de Meia-Idade
2.
Fiziol Cheloveka
; 34(5): 73-9, 2008.
Artigo
em Russo
| MEDLINE
| ID: mdl-18956564